Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimers disease

Journal of Neurology, Neurosurgery & Psychiatry
Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimers disease
Introduction

Subjective cognitive decline (SCD) has been implicated as an early marker of subtle cognitive change in preclinical Alzheimer’s disease (AD).1 The relationship between SCD and molecular markers of disease progression in AD is poorly understood. Carriers of the presenilin (PSEN1 E280A) mutation from the Colombian kindred2 are a compelling group in which to study SCD, as they will develop dementia with certainty, and have a well-characterised disease trajectory from presymptomatic to clinical stages.2

SCD has been associated with markers of AD pathology in older adults at risk for late-onset sporadic AD.3 We showed previously that self-reported subjective memory complaints (SMC), a proxy for SCD, were elevated in cognitively unimpaired PSEN1 mutation carriers, and that study-partner-reported SMCs were correlated with age and negatively correlated with hippocampal volume.4 In the present study, we explored the extent to which SCD…
Source: Journal of Neurology, Neurosurgery & Psychiatry

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