DIFFERENTIAL EFFECTS OF ISCHEMIA-REPERFUSION ON ENDOTHELIAL FUNCTION AND CONTRACTILITY IN DONATION AFTER CIRCULATORY DEATH (DCD)

The Journal of Heart and Lung Transplantation
DIFFERENTIAL EFFECTS OF ISCHEMIA-REPERFUSION ON ENDOTHELIAL FUNCTION AND CONTRACTILITY IN DONATION AFTER CIRCULATORY DEATH (DCD)
Donation after circulatory death (DCD) could significantly improve cardiac graft availability. However, DCD hearts undergo potentially deleterious warm ischemia and reperfusion (I/R). As endothelial damage is a key factor in cardiac I/R injury, we aimed to investigate the tolerance of cardiac and endothelial function following various durations of warm ischemia, in order to improve the timing and choice of cardioprotective therapies.
Source: The Journal of Heart and Lung Transplantation

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