Response to "Reply to: 'The decreasing predictive power of MELD in an era of changing etiology of liver disease'"

American Journal of Transplantation
Response to "Reply to: 'The decreasing predictive power of MELD in an era of changing etiology of liver disease'"

Abstract

We appreciate Kwong et al.’s utilization of Harrell’s c‐statistic and its ability to incorporate follow‐up time as a valuable contribution to the discussion about our group’s findings.1 We acknowledge that the conventional area under receiver‐operating‐characteristic curve concordance statistic has limitations; however, we selected the conventional c‐statistic to remain methodologically consistent with the manner in which the Model for End‐Stage Liver Disease (MELD) was originally designed and validated, first to predict post‐TIPS survival, then when applied to ESLD generally, and finally when integrated into allocation.

Source: American Journal of Transplantation

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